Aplastic Anemia

Aplastic Anemia Treatment: Types, Symptoms, Diagnosed Doctors In India

Aplastic Anemia, also known as Bone Marrow Failure, is a type of rare, but treatable types of anemia. In this condition, the bone marrow doesn’t make enough new blood cells – red blood cells, white blood cells, and platelets. Sometimes, the bone marrow stops making just one type, but more often, the body becomes low on all three types of blood cells.

Anyone and everyone are susceptible to Aplastic Anaemia, but it’s more likely to happen to people in their late teens and early 20s, and the elderly. Males and females, both have an equal chance of getting it.

Different Types of Aplastic Anemia:-  There are two different types of Aplastic Anemia

  • Acquired Aplastic Anemia is more common in adults. Research has shown that the disorder is a result of something triggering problems in the immune system. The probable causes are viruses like HIV or Epstein-Barr; certain medications, toxic chemicals, radiation or chemotherapy etc.
  • Inherited Aplastic Anemia is caused by gene defects. It is most common among children and young adults. People with this type have a high chance of developing leukemia & other cancers.

Symptoms of Aplastic Anemia

Each type of blood cell has a different role: red blood cells carry oxygen around the body; white blood cells fight infections, and platelets prevent bleeding. The symptoms of Aplastic Anemia depend on what type of blood cells in the body is low on: 

  • Symptoms of Low Red Blood Cell Count: Tiredness; Shortness of breath; Dizziness; Pale skin; Headaches; Chest pain; an Irregular heartbeat.
  • Symptoms of Low White Blood Cell Count: Infections; Fever.
  • Symptoms of Low Platelet Count: Easy bruising and bleeding; Nosebleeds.

How is Aplastic Anaemia Diagnosed?

To diagnose Aplastic Anaemia, a GP will refer the patient to a Haematologist, who will recommend the following tests: 

  • Complete Blood Count (CBC) – Normally, red blood cell, white blood cell and platelet levels stay within a certain range, the Haematologist may suspect aplastic anemia when all three of these blood cell levels are very low.
  • Bone Marrow Biopsy – A bone marrow biopsy is the only way to confirm a diagnosis.

Once the diagnosis is confirmed, the Haematologist will recommend additional tests to determine an underlying cause. 

How is Aplastic Anemia Treated?

If the Hematologist identifies the cause of Aplastic Anaemia and gets rid of that trigger, the condition may go away. But, Hematologists can rarely pinpoint the exact cause.

If the condition isn’t severe, the patient may not need treatment unless or until the blood count drops below a certain level. If it does, the Haematologist may prescribe hormones or drugs to help the bone marrow make blood cells along with antibiotics and anti-fungal medications to fight infection.

Most people with Aplastic Anemia will need a blood transfusion at some point.

If the blood count is very low, the Hematologist may suggest a bone marrow or a stem cell transplant boost the body’s ability to make blood cells. In some cases where a transplant is not an option, Hematologists prescribe medication to try and stop the body from attacking the bone marrow.

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Dr. Vikas Dua

Head and Senior Consultant, Pediatric Hematology Oncology, and Bone Marrow Transplant

Dr. Vikas Dua is Paediatric Hemato Oncologist and bone marrow transplant specialist of the generation. Dr. Dua's results in the field of Paediatric Haematology Oncology and BMT have been some of the best. He and his team has done 200 + paediatric transplants. 

About Dr. Rahul Bhargava

Hematologist, Hemato-oncologist & Stem Cell Transplant Physician

With over 20 years of experience, Dr. Rahul Bhargava is currently the Director of Haematology, Paediatric Haematology, Immunology and Stem Cell Transplant at Fortis Memorial Research Institute (FMRI), Gurgaon – India’s first integrated Centre of Excellence in Haematology, Paediatric Haematology, and Stem Cell Transplant.

Dr. Aniruddha Dayama

Hematology, Pediatric Oncology & Bone Marrow Transplant Specialist

Dr. Aniruddha Dayama in 2015 led the efforts to get NMDP, USA approval for one of the leading hospitals in Gurgaon. He and his team have popularised autologous transplants in multiple sclerosis. The team has been credited for establishing six low-cost centers across North India.